View abstract. CNS.Neurol.Disord Drug Targets. Interactions Do not use Chinese skullcap with alcohol or the following Biochim Biophys Acta 1999;1472:643-50. The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. View abstract. Journal of Dietary Supplements 2010;7:253. Int J Mol Med 2004;14(4):627-632. J Ethnopharmacol. View abstract. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Ye F, Wang H, Jiang S, et al. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. - callus, root and suspension cultures of Baikal skullcap (Scutellaria baicalensis); For the obtained selected steadily growing callus cell cultures of medicinal plants of the Baikal skullcap (Scutellaria baicalensis), a preliminary analysis of the growth of the cultures was performed and the growth index was calculated. Unfortunately, some of the supplements containing Scutellaria baicalensis have also resulted in liver toxicity in some cases. Details. CAS #:94279-99-9 | EC #:304-845-9. View abstract. Zhang, X. W., Li, W. F., Li, W. W., Ren, K. H., Fan, C. M., Chen, Y. Y., and Shen, Y. L. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. View abstract. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. 2010;17(10):760-770. Zhang H and Huang J. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. WebThe root of Scutellaria baicalensis is used as medicine. Details. View abstract. Scutellaria Macrantha , Scutellaria Baicalensis, Family: Lamiaceae. 1995;15(8):465-467. The root has been used in Chinese medicine for psychiatric disorders. View abstract. Planta Med 2000;66:91-3. J Ethnopharmacol. View abstract. Letter/Prescriber's Letter. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with integrative cancer therapies. View abstract. Cancer Treat Rev 2009;35(1):57-68. Chinese Journal of Gerontology 2010;30(7):926-928. Planta Med 2000;66:70-1. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. In combination with other herbs, Baikal skullcap is used to treat attention deficit-hyperactivity disorder (ADHD), prostate cancer, a lung condition called bronchiolitis, arthritis, and hemorrhoids. 2000;23(5):272-274. Int Immunopharmacol 2014;23(2):558-67. Zhang, K., Guo, Q. L., You, Q. D., Yang, Y., Zhang, H. W., Yang, L., Gu, H. Y., Qi, Q., Tan, Z., and Wang, X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. View abstract. View abstract. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. View abstract. Kimura, Y. and Sumiyoshi, M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains Baikal skullcap was safely used in research studies lasting up to 12 weeks. You may ask and answer a query. Eksp.Klin Farmakol. View abstract. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. View abstract. It is often used in combination with other herbs. View abstract. Zhao, M., Zhou, Z. T., and Zhang, W. D. [Antifugal susceptibility testing and antifugal traditional Chinese medicines screening of oral Candida isolated from head and neck cancer patients treated with radiotherapy or chemotherapy]. View abstract. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Ai.Zheng. View abstract. Case ReportsAcute liver injury: In patients with arthritis, following consumption of a formula containing baicalin derived from S. baicalensis or Chinese skullcap. J Biomed.Sci 2009;16:27. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Chen C, Mireles RJ, Campbell SD, et al. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. 2009;29(5):1286-1288. 2009;48(12):1159-1169. Int J Cancer 9-10-2003;106(4):559-565. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. However, low doses of baicalin upregulated expression of multiple angiogenic genes to increase cell proliferation in developing blood vessels, while high doses inhibited angiogenesis by inducing cell death, suggesting dose-dependent dual effects. View abstract. J Ethnopharmacol. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Furthermore, this herb has not been treated alone on cancer cells, but it showed results when combined with other herbs and medicines. 2019;133:109402. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Cell Mol Biol Res 1993;39(2):119-124. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Saifutdinov, R. R. and Khazanov, V. A. View abstract. 10-18-2009;41(5):578-584. Zhongguo Zhong.Yao Za Zhi 2007;32(17):1827-1829. Polysaccharides inhibit proliferation and downregulate phospho-c-Met expression and downstream phospho-Erk/Akt signaling(18). View abstract. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Ha, K. T., Kim, J. K., Kang, S. K., Kim, D. W., Lee, Y. C., Kim, H. M., and Kim, C. H. Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Kaplya, O. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. View abstract. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. View abstract. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. View abstract. 2006;63(2):95-96. 4-12-2011;134(3):884-891. Taking Baikal skullcap along with medications that also slow clotting might increase the chances of bruising and bleeding. Baikal skullcap might decrease how quickly the liver breaks down some medications. Limit doses of American skullcap to no more than the package recommendation. Taking Baikal skullcap with these medications might decrease how well the medication works. Clin Pharmacol Ther 2007;82:726-33. Taking Baikal skullcap with medications used to treat high blood pressure might cause blood pressure levels to go to low. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. 2010;17(1):47-54. View abstract. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Biol Pharm Bull 2011;34(5):727-733. Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) It can cause drowsiness, fever, lung inflammation, and other information View abstract. Int J Mol Med 2004;14(4):627-632. View abstract. View abstract. Zhou, X. Q., Liang, H., Lu, X. H., Cai, S. Q., Wang, B., and Zhao, Y. Y. Taking Baikal skullcap along with medications that lower blood pressure might cause blood pressure to go too low. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. View abstract. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For View abstract. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. View abstract. Baikal skullcap might lower blood pressure. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. View abstract. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. The roots of this herb have been used since ancient times, as old as 2000 years in traditional Chinese medicine (TCM). Monitor your blood sugar closely. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. 5-24-2006;105(3):346-351. However, lab tests have shown that it is a herb that can reduce inflammation and have antioxidant properties. China GMP, NSF cGMP,ISO Certifiate, Halal, Kosher Certificate, Scutellaria Baicalensis: Uses Side Effects And Precautions. Beijing Da.Xue.Xue.Bao. View abstract. Kim M, Lee BC. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Intern Med J. Pharmacol.Res. View abstract. View abstract. View abstract. Planta Med 2010;76(7):678-682. 36 Based on previous reports on pharmacological modulation of diabetes, hyperlipidemia and atherosclerosis Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. View abstract. Regulatory effects of gibberellic acid (GA3) on shoot and root formation of Huang-qin (Scutellaria baicalensis) in vitro. Integr.Cancer Ther. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Z., and Liu, Y. W. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. View abstract. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. 12-10-2008;8(12):1652-1657. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. A number of constituents including flavonoids are thought to be responsible for these activities. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Planta Med 2000;66:91-3. Phytomedicine. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. View abstract. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. Planta Med 1998;64:571-2. View abstract. View abstract. J Ethnopharmacol. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. J Ethnopharmacol. View abstract. View abstract. Onco Targets Ther 2016;9:2935-43. Pharmacist's Letter/Prescriber's Letter. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. View abstract. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. Planta Med 2002;68(2):128-132. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. Sasaki, K., Taura, F., Shoyama, Y., and Morimoto, S. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Use of this Web site does not create an expressed or implied physician-patient relationship. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Biull.Eksp.Biol Med 1999;128(9):327-329. View abstract. Some people use Baikal skullcap for HIV/AIDS, kidney infections, pelvic inflammation, and sores or swelling. J Biol Chem 9-1-2000;275(35):27466-27472. Ann Palliat Med. 2-1-2010;84(2):137-144. This is especially relevant to macrophages and immune cells. 2011;31(4):1130-1132. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. S. barbata flavonoids have produced synergistic effects in combination with cisplatin in ovarian cancer cells(32). View abstract. Life Sci 10-27-2000;67(23):2889-2896. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. At least 2 weeks before a scheduled surgery or swelling herbal medicine baicalensis. With arthritis, following consumption of a formula containing baicalin derived from S. or... Med 2010 ; 76 ( 7 ):926-928 or implied physician-patient relationship innate immunity and apoptosis in cancer cells 32... Than the package recommendation regulating lipid metabolism ] 10:278-9, 260 however, lab tests have shown it... 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