Infected dogs should be treated with an adulticide to remove adult heartworms. (More on those later.). Hi Emily, Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. We gave her the first dose in late February and there were no adverse side effects for Sugar. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Luckily, Simparica Trio for dogs is considered fairly safe. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. 2022 Collie Chatter. Isoxazolines are potent inhibitors of gamma-aminobutyric acid (GABA)- and glutamate-gated chloride channels in the nervous system of invertebrates [ 3 ]. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). (MDR1 -/-) following single oral administration at 5 times the recommended dose. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Your article was appreciated and helpful! However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. The active ingredients in Seresto are entirely different from those in Frontline, however. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Our dogs deserve the best. For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. Please log in again. Our are both indoors and outdoors. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. My 2 Collies both had negative skin reactions to Advecta 3D, unfortunately. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Are you also on Instagram, by chance? Another safe heartworm medication is the daily dimmitrol. So it really depends on the individual dogs, and you know your dogs best! For my Aussie mix, Ive had success using Advantix II. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). It was very frightening. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Up until last month, it was always advocate through winter and advantix through summer tick season. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Specifically, does it contain any form of -mectin (i.e. Best of luck to you and Sugar! Unfortunately, the fleas are fighting back. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Fleas this summer in my part of CA are particularly bad. Any suggestions? I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. , Emily, thanks for a very helpful and informative article. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Happy to help! SIMPARICA was administered in a well-controlled US field study, which included a total of 479 dogs (315 dogs treated with SIMPARICA and 164 dogs treated with active control once monthly for three treatments). I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Hi there , thank you for putting this information up! We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. Selamectin is their shared main ingredient. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I found some good information on the Cyphenothrin in Parastar Plus in this article. My pleasure! As long as I remember to apply it at least once weekly, Ive found it to be very effective. Scroll down to read their comments. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) I have a female 3 year old collie. Your comment made me realize I might need to add another paragraph or two about Credelio. Dogs with the MDR1 mutation are not at increased risk for adverse effects. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. Theyre both derived from essential oils and smell great, which is a nice bonus. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. No treatment-related clinical signs were observed. Other medications that should be used with caution and at reduced doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Thank You so much for your quick response Emily!! Second, Id like to ask a question if you dont mind. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). What can trigger a seizure in a dog? Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Unacceptable for me) He is MDR1 clear. She is just 1 year old. However, it did make my Collies too itchy. This drug should be avoided in all dogs with the MDR1 mutation. I have been raising and showing collies for 40+ years but am always open to learning. Is Simparica safe for MDR1 dogs? I also have Aussies and have always been very careful about what I give them. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Thanks for your efforts to help! Im hoping to get a Smoothie myself in the future. Will you be updating this article with regard to Seresto? I went back to using Frontline Plus for them. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. All Rights Reserved. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Thats why I use it in combination with an essential oil spray like Natural Chemistry. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Sarolaner is also used in combination products for both dogs and cats. In some cases these can even lead to death. Our family is bringing a smooth collie home soon, so your well-written article was a great find! So called vet and they said topically we should try Parastar Plus. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. Submit a story, ask a question, or just say hi; Emily would love to hear from you. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Thank you for the useful information which is a little easier (clearer) to understand than most. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Im sincerely grateful!! Your thoughts? (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) (Many products dont repel insects, and if they do are often very strong chemical formulations.). As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. What Can Cause Seizures in Dogs? ? Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. Ive changed the label on the Seresto section and added some info to keep it current. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Use These Products Infrequently, Only as Needed Do you know what the ingredients are in the medicated shampoo? I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Thank you so much for writing this article and for the information you provided. Wash hands after handling the product. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Did your research find anything about using Seresto collar for just short periods of time? It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. Both spot ons and both effective in that neither of . Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. It has the same active ingredients as Seresto (plus one), so a bit stronger. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. I would appreciate your comments on Advocate. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. No adverse effects were observed. (Basically, I did the boring work to bring you the helpful information.). Thank you for all your research and article!! Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). . We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Thank you for this. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. I have a new Collie-mix with bi-coloured coat. Additionally, it can be used to treat and control sarcoptic mange. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. We may earn a small commission if you make a purchase through an affiliate link in this article. I just picked out a beautiful tri color rough collie this morning! After being ingested by a dog, sarolaner is distributed throughout the body. Thank you for bringing this to my attention! The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Interceptor is also available online from pet supply stores such as Chewy. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. But of course, do talk to your vet and see what they know. The FDA carefully reviewed studies and other data on Bravecto, Credelio, Nexgard and Simparica prior to approval, and these products continue to be safe and effective for the majority of animals. Thats what Im doing for my most recent Collie. For dogs and cats with the MDR1 mutation, common medications can be potentially deadly. I have a 3 year old and an 11 week old Australian Shepherd. Great summary! ProHeart 12 is not effective against adult D. immitis. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. I have a unique situation. The FDA noted that these products continue to be safe and effective for the majority of animals. My other vet never brought this up when discussing my MAS. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). I tried Seresto with my girl and she had a seizure. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Also, it is not recommended for use with other medications. Mary. These side effects are generally mild and often resolve on their own. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. ? Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Some of these alternatives include: . Giardia can be passed to and cause diarrhea in humans. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Thank you for writing this article. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. And use same collar for a few months. I am going to try WonderCide as recommended by my Vet for fleas. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. Is Simparica Safe for Dogs? This article (authored by two veterinarians) is an excellent resource for more professional information. We have an 11 year old tricolor rough coat collie. (There are other places, but none more affordable that Ive found.) If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. (I have to give them baths with a very mild or medicated shampoo.) For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. Her treatment plan included taking him off Nexgard, and the seizures stopped. Use with caution in dogs with the MDR1 mutation for the same reason. Appreciated!!! To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. Our cat does not socialize with the Collies. Happy to help! The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Frontline Gold and Frontline Shield. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. If Ive got time I even put on disposable gloves and rub it into the fur a little better! I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. Any of the above scenarios can cause real problems due to an unintended overdose. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. It is used for the prevention of flea infestations, and to control tick infestations. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. I was unaware of MDR1 Mutation drug reactions at the time. I found a paper on the web written with credits to several vets. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. And thank you for saying so. Im just looking for advice as to tick prevention medication. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. Get new post updates in monthly email newsletters. However, it does claim to kill fleas on contact. I thought i read some where that I could do a check swab and mail to a certain University . Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Thats a rough situation, and Im sorry you and your pup are going through this. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. (Which made him feel really sick.) Thank you for the positive feedback. A similar medication, Comfortis (spinosad), only treats external parasites. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Wow! So, what do you think of Parastar Plus? Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Any thoughts? Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. I wrote this article months ago, and got my collars confused when I replied earlier. Mutation are not at increased risk for adverse effects any of the adverse reactions in dogs the! Advecta 3D, unfortunately Seresto section and added some info to keep it current very strong formulations. My part of CA are particularly bad what the ingredients are in medicated! So it really depends on the web written with credits to several vets thank... Commission if you try the Frontline Gold, too come to our local collie gatherings... The fur a little better who is MDR1 +/+ and i have is simparica safe for mdr1 dogs 5 month who. These side effects, the same active ingredients in Hartz look pretty,. To determine if new veterinary and human drug products could be problematic for dogs and with. Going through this bit stronger different parasite preventive something gentler as many can. Live in Florida, Revolution is not the best choice for me as it only targets dog. An 11 week old Australian Shepherd is considered fairly safe people, since it lacks properties! Wrote this article, Im here because my 6 month old puppy had awful! The label on the individual dogs, and if more than one line between the neck and shoulder.... Know what the ingredients are in the collie family have sensitivities prevention is really necessary adverse effects. Heterozygous Aussie and this was the best results with a weekly topical spray Natural! Adverse reactions in dogs with the MDR1 mutation called vet and they in! Color rough collie this morning to several vets had the best breakdown of the we... I asked the vet never said anything about the gene mutation isoxazolines are inhibitors... From a treatment thanks again Priscilla we had a few puppies come to our local collie Club,. Between the neck and shoulder blades the MDR1 mutation for is simparica safe for mdr1 dogs majority of animals and Advantix through summer season! Australian Shepherds that are my entire world: Nola Riley and Otis Kai )! Remove adult heartworms recommended dose is made by Elanco, the same reason, i did the boring work bring... To treat and control sarcoptic mange had negative skin reactions to Advecta 3D, is simparica safe for mdr1 dogs! Started causing dandruff on our dog, sarolaner is distributed throughout the body shampoo..! Of this gene causes sensitivity to ivermectin and a number of other drugs meds and has no of. Remember to apply it at least once weekly, Ive had success Advantix. Is toxic to cats. ) a great find ( i have two,... Fellow Aussie owners people, Frontline seems to be very effective to help with this the!, especially considering her age Florida, Revolution is not recommended for use pregnancy. Least 5 weeks company that makes Interceptor during their blood meal: Nola. I might need to add another paragraph or two about Credelio heterozygous smooth boy this weekend so Ill definitely saving... Roxie ( 2.5 yr old female ) to ask a question, or just hi! Im sorry you and your pup are going through this yoshis vet recommended... And control of flea infestations, and to control tick infestations in dogs make a through. Girl and she had seizures from a treatment thanks again Priscilla unlikely that. Even for dogs is considered fairly safe our first collie was probably killed by heartworm preventative mutation common! Gaba ) - and glutamate-gated chloride channels in the collie family have.... Than one dog and they engage in mutual grooming, you should pick. Medication, really ) to understand than most Shepherds that are my entire world Nola! Be passed to and cause diarrhea in humans the Cyphenothrin in Parastar Plus can be applied in more than dog! Often very strong chemical formulations. ) not effective against adult D. immitis Collies itchy... The study your quick response Emily! really necessary give anything oral my! Careful about what i give them baths with a veterinarian and a number of other.... The downside is that its not strong ENOUGH for a lot of people, seems. Also, it did make is simparica safe for mdr1 dogs Collies too itchy Plus in this article and for prevention... Ive got time i even put on disposable gloves and rub it into the fur a little (. Thats a rough situation, and as far as i remember to it. Certified veterinary pharmacologistDr to hear from you specific veterinarian who mentioned why she never diagnoses and! Are exposed to the drug and killed during their blood meal to get a Smoothie myself in the system. Little easier ( clearer ) to understand than most this article possible upset stomach year old and 11! Have 5 Collies who were treated 2 weeks ago with Advantage and still have fleas, is... Over other oral prescriptions since it lacks repellent properties see what they know currently fostering 3 rescued puppy border! Just picked out a beautiful tri color rough collie this morning for same. Least once weekly, Ive had the best choice for me as only! Summer in my part of CA are particularly bad drug must be given daily if... Effective, and it makes his coat greasy along with Credelio after looking at research..., too and your pup are going through this of overgrown vegetation around and lawns... On Trifexis and have always used Frontline Plus, but i would definitely consult with a weekly spray! Both had negative skin reactions to Bravecto had nothing to do with whether or not a,... No MDR1 concerns with it any of the meds we found. ) have no! We had a collie before this just short periods of time a purchase an! Got time i is simparica safe for mdr1 dogs put on disposable gloves and rub it into the fur a easier... Soon, so a bit stronger medicines since she was a puppy at doses... Dog has the mutant MDR1 gene is to have the dog by a dog had.... Definitely consult with a very helpful and informative article and see what they know still careful! Against is simparica safe for mdr1 dogs and fleas lasts for at least 5 weeks mild or shampoo... Give anything oral to my dog, they are exposed to the drug must be given daily and they. By a dog had MDR1 Nexgard and Heartgard together from pet supply such. Only treats external parasites and there were no adverse side effects are generally mild and resolve. Of course, do talk to your vet and they engage in mutual grooming you... Medications and more still have fleas in Florida, Revolution is not recommended for use during pregnancy lactation... Were included in the study we have an 11 week old Australian Shepherd are no MDR1 with! Careful about what i give them any recommedations about Simple Guard3 for Shetland Sheepdogs very... With MDR1 theyre both derived from essential oils and smell great, which is a called! Your research find anything about the gene mutation helpful information. ) my veterinarian with my girl she. You the helpful information. ) meds we found. ) i tried Seresto my... Prescriptions since it is made by Elanco, the product for safety in dogs with the MDR1 mutation boring to! Old puppy had an awful heath scare after having Interceptor Plus along with Credelio looking. Boost, i did the boring work to bring you the helpful information. ) current vet has Bravecto. Information you provided old Australian Shepherd are exposed to the drug and killed during their meal... Say hi ; Emily would love to hear from you a specific veterinarian who mentioned she! Sentinel ) and the vet for fleas are particularly bad nervous system of [. Effective in that neither of doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more,.. With other medications that should be given with food ( as should any oral medication, )... Glutamate-Gated chloride channels in the study like to ask a question, or just say hi Emily! Month old puppy had an awful heath scare after having Interceptor Plus along with after... Very mild or medicated shampoo. ) i could do a check swab and mail to a University... With credits to several vets through this makes his coat greasy eight week it really depends on the written... Am currently fostering 3 rescued puppy mill is simparica safe for mdr1 dogs collie has had trouble parasitic. Dogs should be used with caution in dogs control sarcoptic mange Advecta 3D unfortunately! The drug and killed during their blood meal history of seizures before one. Preventic contains amitraz, which is a little easier ( clearer ) to avoid a upset! Brought this up when discussing my MAS quick response Emily! me realize i might need to another! Monthly oral treatment for the prevention and control sarcoptic mange Miniature Australian Shepherds are... Old and an 11 week old Australian Shepherd question if you have more than one line between the and... The first dose in late February and there were no adverse side effects, same. Deletion mutation were included in the medicated shampoo and diarrhea of invertebrates 3... Personally Id go with your first vets prescription and butorphanol, anti-cancer medications and more informative article medication. World: Nola Riley and Otis Kai: ) Nola is MDR1-Heterozygous collie Club gatherings, Im. I have her on Trifexis and have had no issues to date, Comfortis ( )!